Treating alcohol dependence

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Drug adjuncts for treating alcohol dependence.

Three drugs are approved by the US Food and Drug Administration for treating alcoholism: disulfiram, naltrexone, and acamprosate. Drugs approved for other indications that are being used experimentally or "off-label" include nalmafene, topiramate, and ondansetron. As we learn more about the pathophysiologic basis of alcoholism, it is hoped that novel drugs can be developed to help people with a...

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A lmost one third of Americans consume enough alcohol to be considered at risk for alcohol dependence, and alcohol abuse and dependence are associated with more than 100,000 deaths from alcohol-related diseases and injuries each year. The economic cost of alcohol abuse and dependence was estimated at more than $184 billion for 1998.1 Use of screening tools and brief primary care interventions f...

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Treating tobacco dependence

Most cigarettes contain around 10 mg of nicotine, about 1 mg of which is actually absorbed by inhalation of smoke. An average smoker awakens in the morning with blood nicotine levels of less than 5 ng/ml (the half-life of nicotine is about two hours). Afternoon nicotine levels are generally in the range of 15-80 ng/ml. The typical nicotine boost from an afternoon cigarette is 10-15 ng/ml (Fould...

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Rimonabant for treating tobacco dependence

Tobacco use continues to cause 5 million preventable deaths worldwide each year. Despite effective treatments being available, these are underutilized and cessation rates remain low. As tobacco use has complex physiological effects, there are multiple opportunities for novel pharmacological agents to play a role in a comprehensive treatment plan. The endocannabinoid system has been linked to th...

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ژورنال

عنوان ژورنال: BMJ

سال: 1997

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.315.7120.1465a